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Avapritinib

Blueprint Medicines announced the European Commission has approved AYVAKYT® (avapritinib) for the treatment of adult patients with indolent systemic mastocytosis (ISM) with moderate to severe symptoms inadequately controlled on symptomatic treatment. AYVAKYT is the first and only approved therapy for people living with ISM in Europe.  AYVAKYT was designed to potently and selectively target KIT D816V, the primary underlying driver of the disease.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.

6-bromo-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
6-bromo-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
CM103536
888721-83-3
4-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine
4-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine
CM329513
1703794-33-5
ethyl 2-chloropyrimidine-5-carboxylate
ethyl 2-chloropyrimidine-5-carboxylate
CM108980
89793-12-4
N-Boc-piperazine
N-Boc-piperazine
CM103943
57260-71-6
2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylic acid
2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylic acid
CM335238
253315-11-6
tert-butyl 4-[5-(4-fluorobenzoyl)pyrimidin-2-yl]piperazine-1-carboxylate
tert-butyl 4-[5-(4-fluorobenzoyl)pyrimidin-2-yl]piperazine-1-carboxylate
CM327278
1703794-73-3
(4-fluorophenyl)-(2-piperazin-1-ylpyrimidin-5-yl)methanone;hydrochloride
(4-fluorophenyl)-(2-piperazin-1-ylpyrimidin-5-yl)methanone;hydrochloride
CM327493
1703795-52-1