Название продукции:Pyrido[3,4-b]pyrazine-2,3(1H,4H)-dione
IUPAC Name:1H,2H,3H,4H-pyrido[3,4-b]pyrazine-2,3-dione
- CAS:35251-84-4
- Молекулярная формула:C7H5N3O2
- Чистота:97%
- Номер в каталоге:CM214023
- Молекулярная масса:163.14
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Информация о продукции
- Номер CAS:35251-84-4
- Молекулярная формула:C7H5N3O2
- Точка плавления:-
- Smiles-код:O=C1NC=2C=NC=CC2NC1=O
- Плотность:
- Номер в каталоге:CM214023
- Молекулярная масса:163.14
- Точка кипения:
- Номер Mdl:MFCD01411816
- Хранение:
Category Infos
- Quinazolines
- Quinazolines belong to heterocyclic chemistry, also known as 1,3-naphthalenes. The backbone consists of two six-membered aromatic rings fused to each other, with two nitrogen atoms at positions 1 and 3 on the backbone. The presence of these two nitrogen atoms in quinazoline increases its importance in pharmaceutical and biological reactions. Quinazolines and their derivatives are among the most important heterocyclic compounds due to their diverse chemical reactivity and important range of biological activities.
Column Infos
- CVN424
- In a Phase 2 clinical trial, CVN424, a novel, non-dopaminergic, GPR6 inverse agonist, demonstrated a significant reduction in OFF time and was safe and well tolerated with low rates of mostly mild and moderate adverse events. Patients also reported enhanced motor functionality in daily activities, as assessed by the UPDRS Part II. These findings enhance the confidence in CVN424's potential to address both motor and non-motor symptoms of Parkinson’s disease, consistent with observations in pre-clinical models, potentially heralding a transformative non-dopaminergic therapy.
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