Название продукции:5-Formyl-4-methyl-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-1H-indole-2-carbonitrile
IUPAC Name:5-formyl-1-[(2S)-2-(4-methanesulfonylpiperazin-1-yl)propyl]-4-methyl-1H-indole-2-carbonitrile
- CAS:2437331-14-9
- Молекулярная формула:C19H24N4O3S
- Чистота:95%+
- Номер в каталоге:CM1075328
- Молекулярная масса:388.49
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Информация о продукции
- Номер CAS:2437331-14-9
- Молекулярная формула:C19H24N4O3S
- Точка плавления:-
- Smiles-код:C([C@H](C)N1CCN(S(C)(=O)=O)CC1)N2C=3C(C=C2C#N)=C(C)C(C=O)=CC3
- Плотность:
- Номер в каталоге:CM1075328
- Молекулярная масса:388.49
- Точка кипения:
- Номер Mdl:
- Хранение:
Category Infos
- Indoles
- Indole is a compound of pyrrole and benzene in parallel, also known as benzopyrrole. There are two combinations of pyrrole and benzene, called indole and isoindole, respectively. Many derivatives of indole have physiological and pharmacological activities, and can synthesize vasodilators, antihistamines, antipyretic analgesics, etc. in medicine, so indole is also a very important heterocyclic compound.
- indole company
- As a indole company,we sincerely welcome the new and old friends from home and abroad to synergize with our company and share the benefits and opportunities.
Column Infos
- Ziftomenib
- Kura Oncology reported preliminary clinical data from the first 20 patients in KOMET-007, a Phase 1 dose-escalation trial of the Company's potent and selective menin inhibitor, ziftomenib, in combination with standards of care, including cytarabine/daunorubicin (7+3) and venetoclax/azacitidine (ven/aza), in patients with NPM1-mutant (NPM1-m) and KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML). Ziftomenib is a novel, once-daily, oral investigational drug candidate targeting the menin-KMT2A/MLL protein-protein interaction for treatment of genetically defined AML patients with high unmet need. In preclinical models, ziftomenib inhibits the KMT2A/MLL protein complex and exhibits downstream effects on HOXA9/MEIS1 expression and potent anti-leukemic activity in genetically defined preclinical models of AML. Ziftomenib has received Orphan Drug Designation from the FDA for the treatment of AML.
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