Название продукции:N-ethyl-3,3-difluoro-N-(oxetan-3-yl)cyclobutane-1-carboxamide
IUPAC Name:N-ethyl-3,3-difluoro-N-(oxetan-3-yl)cyclobutane-1-carboxamide
- CAS：2093788-62-4
- Молекулярная формула：C10H15F2NO2
- Чистота：95%+
- Номер в каталоге：CM1024748
- Молекулярная масса：219.23
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Информация о продукции
- Номер CAS:2093788-62-4
- Молекулярная формула:C10H15F2NO2
- Точка плавления:-
- Smiles-код:CCN(C1COC1)C(=O)C1CC(F)(F)C1
- Плотность:
- Номер в каталоге:CM1024748
- Молекулярная масса:219.23
- Точка кипения:
- Номер Mdl:
- Хранение:
Category Infos
- Fluorinated Compounds
- Fluorine is the most electronegative element in the periodic table, and the fluorine atom has a small atomic radius, so fluorine-containing organic compounds have many wonderful properties. For example, the introduction of fluorine atoms or fluorine-containing groups into drug molecules can improve the permeability to cell membranes, metabolic stability and bioavailability; in addition, the introduction of fluorine atoms will improve the lipid solubility of the compound and promote its absorption in the body. The speed of delivery changes the physiological effect. In the field of medicinal chemistry, the introduction of fluorine atoms into organic molecules is an important direction for the development of new anticancer drugs, antitumor drugs, antiviral agents, anti-inflammatory drugs, and central nervous system drugs.
- Cyclobutanes
- The molecular structure of cyclobutane has four carbon atoms, and its four carbon atoms are not in the same plane, which is the folded conformation of cyclobutane. Cyclobutane itself is not of commercial or biological interest, but more complex derivatives are important in biology and biotechnology. Currently, nine FDA-approved drugs contain the cyclobutane structure. From the perspective of therapeutic areas, cyclobutyl drugs are mainly distributed in popular areas such as tumors, neurological diseases, infectious diseases, endocrine and metabolic diseases.
- Oxetanes
- Oxygen heterocycles are one of the most common heterocycles in drugs and natural products. Oxetene has high polarity and is also a good acceptor for hydrogen bond, which contributes to the metabolism and chemical stability of its host molecules. When substituted for commonly used functional groups such as gem dimethyl or carbonyl, oxetane units can induce profound changes in water solubility, lipophilicity, metabolic stability and conformational preference. Four of the FDA-approved drugs contain oxetenes: Orlistat, Paclitaxel, and two of its derivatives, Docetaxel and Cabazitaxel. Currently, oxetane-containing building blocks are flourishing in medicinal chemistry and drug discovery.
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