cas 17507-56-1|| where to buy Ethyl 2-diazo-2-(diethoxyphosphoryl)acetate

Название продукции:Ethyl 2-diazo-2-(diethoxyphosphoryl)acetate

IUPAC Name:ethyl 2-diazo-2-(diethoxyphosphoryl)acetate

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: Номер CAS:17507-56-1; Молекулярная формула:C8H15N2O5P; Точка плавления:-; Smiles-код:[N-]=[N+]=C(C(=O)OCC)P(=O)(OCC)OCC; Плотность:

: Номер в каталоге:CM1075898; Молекулярная масса:250.19; Точка кипения:; Номер Mdl:; Хранение:

: ORIC-533; ORIC-533 is a potential best-in-class, oral inhibitor of CD73 developed by ORIC Pharmaceuticals which is currently in a Ph. Ib trial for the treatment of relapsed/refractory multiple myeloma (MM). It inhibits the CD73-mediated conversion of AMP to adenosine which generates an immunosuppressive tumor microenvironment and has the potential to be a next-generation immunotherapy. The in-depth use of co-crystal structures led the team to discover a novel set of phosphonate bioisosteres which were able to achieve bioavailability for a highly polar scaffold. The structure and discovery story of ORIC-533 were recently presented at the ACS Spring 2024 Meeting in New Orleans.
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