Название продукции:tert-Butyl N-[(1R)-1-methyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]carbamate
IUPAC Name:tert-butyl N-[(2R)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propan-2-yl]carbamate
- CAS:1505515-80-9
- Молекулярная формула:C20H32BNO5
- Чистота:95%+
- Номер в каталоге:CM1079407
- Молекулярная масса:377.29
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Информация о продукции
- Номер CAS:1505515-80-9
- Молекулярная формула:C20H32BNO5
- Точка плавления:-
- Smiles-код:CC1(C)OB(OC1(C)C)C2=CC=C(OC[C@H](NC(OC(C)(C)C)=O)C)C=C2
- Плотность:1.07±0.1 g/cm3
- Номер в каталоге:CM1079407
- Молекулярная масса:377.29
- Точка кипения:493.5±30.0 °C
- Номер Mdl:
- Хранение:
Category Infos
- Boronic Acids and Esters
- Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API).
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Column Infos
- Taletrectinib
- Recently, Nuvation Bio announced positive pooled data from the pivotal Phase 2 TRUST-I and TRUST-II studies at the European Society for Medical Oncology (ESMO). Analysis showed that its small molecule taletrectinib, a new highly selective ROS1/NTRK kinase inhibitor, can cross the patient's blood-brain barrier to treat brain metastases, and nearly 90% of patients with advanced ROS1-positive non-small cell lung cancer (NSCLC) who received treatment had tumor shrinkage. In patients who had never been treated with tyrosine kinase inhibitors (TKIs), disease remission was sustained for nearly 4 years. Nuvation Bio plans to submit a new drug application (NDA) for the drug to the FDA in the fourth quarter of this year.
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