Название продукции:methyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxetane-3-carboxylate

IUPAC Name:methyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxetane-3-carboxylate

CAS:1423702-68-4
Молекулярная формула:C17H23BO5
Чистота:95%+
Номер в каталоге:CM1018226
Молекулярная масса:318.18

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Информация о продукции

Номер CAS:1423702-68-4
Молекулярная формула:C17H23BO5
Точка плавления:-
Smiles-код:COC(=O)C1(COC1)C1=CC=C(C=C1)B1OC(C)(C)C(C)(C)O1
Плотность:
Номер в каталоге:CM1018226
Молекулярная масса:318.18
Точка кипения:
Номер Mdl:
Хранение:

Category Infos

Boronic Acids and Esters
Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API).
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Oxetanes
Oxygen heterocycles are one of the most common heterocycles in drugs and natural products. Oxetene has high polarity and is also a good acceptor for hydrogen bond, which contributes to the metabolism and chemical stability of its host molecules. When substituted for commonly used functional groups such as gem dimethyl or carbonyl, oxetane units can induce profound changes in water solubility, lipophilicity, metabolic stability and conformational preference. Four of the FDA-approved drugs contain oxetenes: Orlistat, Paclitaxel, and two of its derivatives, Docetaxel and Cabazitaxel. Currently, oxetane-containing building blocks are flourishing in medicinal chemistry and drug discovery.

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