Название продукции:1-propylazetidin-3-ol
IUPAC Name:1-propylazetidin-3-ol
- CAS:1340301-52-1
- Молекулярная формула:C6H13NO
- Чистота:95%+
- Номер в каталоге:CM746619
- Молекулярная масса:115.18
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Информация о продукции
- Номер CAS:1340301-52-1
- Молекулярная формула:C6H13NO
- Точка плавления:-
- Smiles-код:CCCN1CC(O)C1
- Плотность:
- Номер в каталоге:CM746619
- Молекулярная масса:115.18
- Точка кипения:
- Номер Mdl:MFCD18308893
- Хранение:
Category Infos
- Azetidines
- Azetidines are an important class of saturated four-membered nitrogen-containing heterocyclic compounds. The research hotspots related to this structure mainly focus on two aspects: one is the research of pharmaceutical chemistry; the other is related to chiral azetidines, using rigid azetidine compounds as chiral ligands for asymmetric catalytic reactions. Many nitrogen-containing heterocycles play important roles in drug structures, and in many cases small structural changes can improve ligand selectivity and pharmacokinetic properties.
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Column Infos
- Palazestrant
- Olema Oncology is advancing the development of Palazestrant (OP-1250) in metastatic breast cancer in 2024. Palazestrant is an oral complete ER antagonist (CERAN) and selective ER degrader (SERD). It potently binds and completely blocks transcriptional activity of both wild-type and ESR1-mutant ER with favorable tolerability and anti-tumor activity.
Palazestrant is under clinical development both in combination with Novartis' CDK4/6 inhibitor Kisqali (Ribociclib) as a first-line therapy for advanced estrogen receptor-positive, HER2-negative breast cancer, and as a monotherapy compared to standard of care treatment in second- and third-line advanced or metastatic ER-positive, HER2-negative breast cancer.