Название продукции:beta-D-Ribofuranose 1,2,3,5-tetraacetate
IUPAC Name:[(2R,3R,4R,5S)-3,4,5-tris(acetyloxy)oxolan-2-yl]methyl acetate
- CAS：13035-61-5
- Молекулярная формула：C13H18O9
- Чистота：97%
- Номер в каталоге：CM100813
- Молекулярная масса：318.28
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Информация о продукции
- Номер CAS:13035-61-5
- Молекулярная формула:C13H18O9
- Точка плавления:-
- Smiles-код:CC(O[C@H]1[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)=O
- Плотность:1.417g/cm3
- Номер в каталоге:CM100813
- Молекулярная масса:318.28
- Точка кипения:385.6°C at 760 mmHg
- Номер Mdl:MFCD00005358
- Хранение:Store at 2-8°C.
Category Infos
- Carbohydrates
- Carbohydrates are polyhydroxy aldehydes (aldoses) or polyhydroxy ketones (ketoses) composed of C, H and O, or form polyhydroxy aldehydes or ketones upon hydrolysis. Carbohydrates come in the form of monosaccharides, disaccharides, oligosaccharides and polysaccharides. The simplest sugars, monosaccharides and disaccharides, consist of one or two monosaccharide units. Oligosaccharides are generally classified as carbohydrates containing 3-10 monosaccharide units. Polysaccharides contain more than 10 monosaccharide units and can be quite large. Glucose is an aldose, the most important monosaccharide in the body, used by cells as fuel. Other aldohexoses are galactose and mannose, which form part of complex molecules. Fructose is a ketohexose sugar, while ribose is the most important aldose pentose sugar and a component of RNA.
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Column Infos
- Quemliclustat
- Data from a phase 1b study of Quemliclustat-based regimens showed promising overall survival in treatment-naïve metastatic pancreatic cancer. Median Overall Survival was 15.7 months for all patients treated with 100 mg quemliclustat-based regimens in the ARC-8 study, which exceeds the historical benchmark data for chemotherapy alone.
Quemliclustat is an investigational, potent and selective small molecule CD73 inhibitor. CD73 is the primary enzymatic producer of immunosuppressive adenosine in the tumor microenvironment, and high CD73 expression is associated with significantly poorer prognosis in several tumor types. Quemliclustat has been shown to block the production of adenosine. Once the immunosuppressive effects of adenosine are removed, activation of antitumor immune cells may be restored, resulting in cancer cell death.
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