Название продукции:(4-(1-methyl-1H-pyrazol-4-yl)phenyl)methanamine
IUPAC Name:1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methanamine
- CAS:1184589-25-0
- Молекулярная формула:C11H13N3
- Чистота:95%+
- Номер в каталоге:CM362822
- Молекулярная масса:187.25
Только для использования в НИОКР..
Информация о продукции
- Номер CAS:1184589-25-0
- Молекулярная формула:C11H13N3
- Точка плавления:-
- Smiles-код:CN1C=C(C=N1)C1=CC=C(CN)C=C1
- Плотность:
- Номер в каталоге:CM362822
- Молекулярная масса:187.25
- Точка кипения:
- Номер Mdl:
- Хранение:
Category Infos
- Pyrazoles
- Pyrazoles are organic compounds of the general formula C3H3N2H. It is a five-membered heterocycle consisting of three carbon atoms and two adjacent nitrogen atoms. As an H-bond-donating heterocycle, pyrazole has been used as a more lipophilic and metabolically more stable bioisomer of phenol. Pyrazoles have attracted more and more attention due to their broad spectrum of action and strong efficacy.
- Pyrazone
- Custom pyrazone for customers from all over the world are our main business.
Column Infos
- IDRX-42
- IDRx announces $120 million series B financing to advance potential best-in-class new treatment for gastrointestinal stromal tumor (GIST). IDRX-42 is a potent, oral, highly selective KIT inhibitor targeting all major categories of activating and resistance mutations in patients with KIT-mutant GIST (including variants in exons 9, 11, 13 and 17). IDRX-42 was granted Orphan Drug designation by the FDA for the treatment of GIST. IDRX-42 is currently being evaluated in StrateGIST 1, a first-in-human Phase 1/1b study.
In preclinical studies, IDRX-42 demonstrated superior antitumor activity compared to imatinib, the current first-line of therapy, in GIST human xenograft models expressing mutations in KIT exons 9 and 11. In xenograft models expressing secondary resistance mutations in KIT exon 13 or 17, IDRX-42 treatment resulted in potent and dose-dependent antitumor activity superior to the second-line standard of care agent, sunitinib.