Название продукции:3-Bromo-6-chloroimidazo[1,2-b]pyridazine
IUPAC Name:3-bromo-6-chloroimidazo[1,2-b]pyridazine
- CAS:13526-66-4
- Молекулярная формула:C6H3BrClN3
- Чистота:95%+
- Номер в каталоге:CM164495
- Молекулярная масса:232.47
Только для использования в НИОКР..
Информация о продукции
- Номер CAS:13526-66-4
- Молекулярная формула:C6H3BrClN3
- Точка плавления:-
- Smiles-код:ClC1=NN2C(Br)=CN=C2C=C1
- Плотность:
- Номер в каталоге:CM164495
- Молекулярная масса:232.47
- Точка кипения:
- Номер Mdl:MFCD09027274
- Хранение:Store at 2-8°C.
Category Infos
- Imidazopyridazines
- Potent IRAK-4 inhibitors have been reported by several groups including some structurally related benzimidazoles as well as alternative fused heterocycles such as the imidazopyridine and imidazopyridazine. Such compounds are reported to have IRAK-1 and IRAK-4 activity with varying degrees of selectivity.
Column Infos
- Taletrectinib
- Recently, Nuvation Bio announced positive pooled data from the pivotal Phase 2 TRUST-I and TRUST-II studies at the European Society for Medical Oncology (ESMO). Analysis showed that its small molecule taletrectinib, a new highly selective ROS1/NTRK kinase inhibitor, can cross the patient's blood-brain barrier to treat brain metastases, and nearly 90% of patients with advanced ROS1-positive non-small cell lung cancer (NSCLC) who received treatment had tumor shrinkage. In patients who had never been treated with tyrosine kinase inhibitors (TKIs), disease remission was sustained for nearly 4 years. Nuvation Bio plans to submit a new drug application (NDA) for the drug to the FDA in the fourth quarter of this year.
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